Recently Google Project Zero team has identified a vulnerabilities on CPU that is affecting all AMD, Intel and ARM Processors.
The variants of the issue identified so far,
Variant 1: bounds check bypass (CVE-2017-5753)
Variant 2: branch target injection (CVE-2017-5715)
Variant 3: rogue data cache load (CVE-2017-5754)
The entire Azure / Office 365 platform from Microsoft is being patched and rebooted as a matter of priority to resolve this problem. You might have already got notification to do a redeploy at your convenience or MS would have forced it last week.
To take care of the on-prem infrastructure, MS has released patches
No patches will be available for Windows XP, Vista, 2000, 2003 etc.
These patches only mitigate the exposure of vulnerability but not resolve. You MUST update your infrastructure as soon as possible and also check for any manufacture update like BIOS or driver updates
*Google Chrome, IE, Firefox also got some updates last week to handle this vulnerabilities.
Hope this information was useful.